The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Dec. 09, 1997
Filed:
Mar. 15, 1994
Bruce A McClane, Pittsburgh, PA (US);
Philip C Hanna, Charlestown, MA (US);
Timothy A Mietzner, Pittsburgh, PA (US);
University of Pittsburgh of the Commonwealth System of Higher Education, Pittsburgh, PA (US);
Abstract
Escherichia coli strains that produce recombinant Clostridium perfringens type A enterotoxin toxoids from a Clostridium perfringens type A enterotoxin gene fragment encoding the Clostridium perfringens type A enterotoxin binding domain subcloned into an expression vector for forming plasmids are disclosed. The Clostridium perfringens type A enterotoxin toxoids of this invention recognize, irreversibly bind to and saturate receptor sites on intestinal membranes and, thus effectively compete for these receptor sites with Clostridium perfringens type A enterotoxin. The toxoids of this invention may be used to treat the symptoms of Clostridium perfringens food poisoning in patients. Vaccines are also disclosed that may be used to prevent the symptoms of Clostridium perfringens food poisoning in patients. Processes for preparing the plasmids and toxoids of this invention and for using the toxoids and vaccines of this invention are also provided.