Company Filing History:
Years Active: 2023
Title: Innovations by Brij Mohan Bhushan in Organ-on-Chip Technology
Introduction
Brij Mohan Bhushan is an accomplished inventor based in Cambridge, MA (US). He has made significant contributions to the field of organ-on-chip technology, holding 2 patents that enhance the functionality and efficiency of biomedical applications.
Latest Patents
His latest patents include innovative designs for pumps and hardware specifically tailored for organ-on-chip platforms. The first patent focuses on on-platform pumps that provide greater flexibility and design freedom. These electromagnetic (EM) pumps are designed for portability, utilizing electrical energy supplied by a battery. The EM actuator features a low energy consumption design, achieved through a latching mechanism that requires only a brief pulse of energy to switch states. This design also incorporates springs that store kinetic energy, which is recovered during the reverse stroke, further minimizing energy usage. Additionally, the patent includes injection-molded, single-use platforms equipped with diaphragm micro-pumps and various valve and pump geometries, demonstrating consistent flow rates and effective valve sealing against varying back-pressure.
The second patent presents a modular organ microphysiological system that integrates pumping, leveling, and sensing capabilities. This fluidic multiwell bioreactor serves as a microphysiological platform for in vitro investigations of multi-organ interactions over extended periods. The platform boasts several enhancements over existing bioreactors, including on-board pumping for fluid flow, a self-leveling spillway, and a built-in fluid level sensing device. It allows for precise control of fluid flow profiles and easy reconfigurations, making it suitable for a wide range of biomedical applications, including systemic toxicity studies and pharmacokinetic predictions.
Career Highlights
Brij Mohan Bhushan is affiliated with the Massachusetts Institute of Technology, where he continues to push the boundaries of research in organ-on-chip technology. His work is instrumental in advancing the understanding of multi-organ interactions and their implications in biomedical research.
Collaborations
He collaborates with notable colleagues such as David L. Trumper and Linda G. Griffith, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Brij Mohan Bhushan's contributions to organ-on-chip technology through his patents exemplify the potential of innovative solutions in biomedical research. His work not only enhances the functionality of organ-on-chip platforms but also paves the way for future advancements