Location History:
- Webster Groves, MO (US) (2005)
- St Louis, MO (US) (2020 - 2021)
- St. Louis, MO (US) (2005 - 2023)
Company Filing History:
Years Active: 2005-2023
Title: Brian W. Ward: Innovator in Genome Sequencing Technologies
Introduction
Brian W. Ward is a prominent inventor based in St. Louis, MO (US), known for his significant contributions to the field of genome sequencing. With a total of 12 patents to his name, he has made remarkable advancements in methods for identifying rare and unknown DNA sequences.
Latest Patents
Among his latest patents are innovative methods for next-generation genome walking and related compositions and kits. These methods provide a framework for identifying rare and/or unknown DNA sequences through next-generation sequencing approaches. The process involves fragmenting isolated double-stranded (ds), single-stranded (ss), or ds/ss DNA, followed by polishing, phosphorylating, and tailing the fragments as necessary. The fragmentation can be achieved through enzymatic or mechanical means. A universal adapter sequence is then ligated to each fragment, which can include specific modifications to enhance the sequencing process. Additionally, he has developed methods for single primer to dual primer amplicon switching, which allows for the conversion of single primer PCR amplicons to dual primer PCR amplicons.
Career Highlights
Brian W. Ward has established a successful career at Sigma-Aldrich Co. LLC, where he has been instrumental in advancing genomic technologies. His work has not only contributed to scientific knowledge but has also paved the way for practical applications in various fields, including medicine and biotechnology.
Collaborations
Throughout his career, Brian has collaborated with notable colleagues such as David M. Ornitz and Thomas F. Bittick. These collaborations have further enriched his research and have led to the development of innovative solutions in genome sequencing.
Conclusion
Brian W. Ward's contributions to genome sequencing technologies exemplify the impact of innovation in the scientific community. His patents and collaborative efforts continue to influence advancements in the field, showcasing the importance of research and development in understanding genetic information.