Company Filing History:
4 out of 5 
2 out of 5,450 
1 out of 1 Years Active: 1998-2003
Title: Innovations and Contributions of Bradford E Windle
Introduction
Bradford E Windle is a notable inventor based in San Antonio, TX (US). He has made significant contributions to the field of biotechnology, particularly in the areas of DNA manipulation and telomerase modulation. With a total of 6 patents, his work has implications for cancer treatment and genetic research.
Latest Patents
One of Windle's latest patents is focused on "Methods and compositions for extended and super-extended DNA and hybridization mapping." This invention relates to the preparation and methods of use of novel extended and super-extended forms of DNA. These forms of DNA are stretched to a substantially linear form up to about 0.6 µm per kilobase pair. The extended DNA can be hybridized with suitably labeled probes and visualized directly. This allows for rapid and efficient determination of gene order and distance with a resolution down to 0.4 kb using fluorescent hybridization techniques.
Another significant patent involves "Methods for modulation and inhibition of telomerase." It was discovered that normal human stem cells produce a regulated non-processive telomerase activity, while cancer cells exhibit a processive telomerase activity. Nucleotide analogs, such as 7-deaza-2′-deoxyquanosine-5′-triphosphate (7-deaza-dGTP), were found to be substrates for processive telomerase and incorporated into telomeric sequences. This incorporation affects the processivity of telomerase, converting it from a processive to a non-processive form. The research has led to the design of new telomerase inhibitors and modulators, which have potential applications in cancer treatment.
Career Highlights
Windle has worked with prominent organizations such as the CTRC Research Foundation and the University of Texas System. His work in these institutions has allowed him to advance his research and contribute to significant scientific discoveries.
Collaborations
Some of his notable coworkers include Shih-Fong Chen and Ira Maine. Their collaborative efforts have further enriched the research landscape in which Windle operates.
Conclusion
Bradford E Windle's innovative work in DNA manipulation and telomerase modulation has made a substantial impact on biotechnology and cancer research. His patents reflect a commitment to advancing scientific knowledge and developing potential treatments for serious health conditions.