Bori Shushan

Title: Bori Shushan: Innovator in Frontal Affinity Chromatography

Introduction

Bori Shushan is a notable inventor based in Toronto, Canada. He has made significant contributions to the field of analytical chemistry, particularly through his innovative patent related to frontal affinity chromatography.

Latest Patents

Bori Shushan holds a patent for a method involving frontal affinity chromatography combined with MALDI tandem mass spectrometry. His invention utilizes sol-gel derived monolithic silica columns that contain entrapped dihydrofolate reductase. This method allows for the effective separation of small molecule mixtures. The output from the column is combined with a matrix molecule (HCCA) and deposited onto a conventional MALDI plate. This process is controlled by a computer-operated x-y stage, creating a semi-permanent record of the frontal affinity chromatography run. The integration of MALDI mass spectrometry enables the use of significantly higher ionic strength buffers, which enhances the retention of protein activity across multiple runs.

Career Highlights

Bori Shushan's career is marked by his dedication to advancing analytical techniques in chemistry. His innovative approach has led to the development of methods that improve the efficiency and effectiveness of protein analysis.

Collaborations

Bori has collaborated with notable colleagues, including William R Davidson and Peter Kovarik, contributing to the advancement of research in his field.

Conclusion

Bori Shushan's work in frontal affinity chromatography and mass spectrometry exemplifies the impact of innovative thinking in scientific research. His contributions continue to influence the field of analytical chemistry.