Company Filing History:
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Years Active: 2010-2012
Title: Boliang Cao: Innovator in Monoclonal Antibody Development
Introduction
Boliang Cao, an innovative inventor based in Ada, MI, has made significant strides in the field of biotechnology, specifically focusing on monoclonal antibodies. With a notable portfolio of three patents, his contributions are vital to cancer research and therapeutic advancements.
Latest Patents
Cao's most recent patents include groundbreaking work on a monoclonal antibody that binds cMet (HGFR) in formalin-fixed and paraffin-embedded tissues, a critical element in understanding aggressive and metastatic cancers. The disclosed monoclonal antibody, named Met4, is specific for the Met receptor, which is associated with poor clinical prognosis in various human solid tumors. This patent outlines both the antibody and the hybridoma cell line that produces Met4, emphasizing its utility in tissue detection for diagnosis, prognosis, and therapeutic efficacy evaluation.
Another significant patent involves antibody fragments, known as Fabs and scFvs, that are specific to the Met receptor. These novel fragments can be internalized into cells, promising advancements in cancer diagnosis, treatment, and evaluation of chemotherapeutic responses. The compositions developed for these fragments are pivotal in creating improved drug and imaging conjugates.
Career Highlights
Throughout his career, Boliang Cao has been affiliated with prestigious research institutions, including the Van Andel Research Institute and the Fred Hutchinson Cancer Research Center. His expertise in monoclonal antibody development has established him as a key figure in cancer research.
Collaborations
Cao has also worked alongside prominent researchers such as George F. Vande Woude and Beatrice S. Knudsen, contributing to collaborative efforts aimed at enhancing the understanding and treatment of cancer through innovative biotechnological approaches.
Conclusion
Boliang Cao's work exemplifies the type of innovations that pave the way for new therapies in cancer treatment. His patents not only reflect his dedication to advancing scientific knowledge but also highlight the importance of collaborative efforts in the field of medical research. Through his inventions, he continues to impact the landscape of biotechnology and cancer diagnosis.