The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 13, 2012
Filed:
Aug. 25, 2008
Boliang Cao, Ada, MI (US);
George F. Vande Woude, Ada, MI (US);
Beatrice S. Knudsen, Seattle, WA (US);
Ping Xu Zhao, Grand Rapids, MI (US);
Boliang Cao, Ada, MI (US);
George F. Vande Woude, Ada, MI (US);
Beatrice S. Knudsen, Seattle, WA (US);
Ping Xu Zhao, Grand Rapids, MI (US);
Van Andel Research Institute, Grand Rapids, MI (US);
Fred Hutchinson Cancer Research Center, Seattle, WA (US);
Abstract
In a wide variety of human solid tumors, an aggressive, metastatic phenotype and poor clinical prognosis are associated with expression of the receptor tyrosine kinase Met. Disclosed herein are (a) a monoclonal antibody named Met4, which antibody is specific for Met, and (b) a hybridoma cell line that produces Met4. The Met4 antibody is particularly useful for detecting Met in formalin-fixed tissue. Methods of using the Met4 antibody for detection, diagnosis, prognosis, and evaluating therapeutic efficacy are provided.