Bjørn Gunnar Voldborg

Title: **Bjørn Gunnar Voldborg: Innovator in Glycosylation and Recombinant Protein Production**

Introduction

Bjørn Gunnar Voldborg is a prominent inventor based in Hillerød, Denmark, recognized for his significant contributions to the field of biochemistry. With a focus on glycosylation and the production of recombinant proteins, Voldborg holds two patents that showcase his innovative methodologies and advancements in biological engineering.

Latest Patents

1. **Glycosylation of Proteins**: This patent involves methods to shift the glycosylation profile of recombinant produced glycoproteins to the predominant bi-antennary form found in human plasma. The innovation includes the use of a mammalian cell line modified with specific gene disruptions and/or insertions to facilitate this critical shift in glycosylation.

2. **Engineered Mammalian Cells for Production of Recombinant Proteins**: This patent relates to mammalian cells that have been modified to enhance the expression of a recombinant protein of interest. The focus is particularly on Chinese hamster ovary (CHO) cells, where the expression of one or more endogenous secreted proteins has been disrupted. This invention outlines the preparation, identification, and application of such modified cells in the production of recombinant proteins.

Career Highlights

Bjørn's career has been marked by his associations with leading research institutions, including Danmarks Tekniske Universitet (Technical University of Denmark) and the University of California. His innovative work has contributed significantly to the advancement of techniques in protein engineering, particularly in the fields of biotechnology and pharmaceutical development.

Collaborations

Throughout his career, Voldborg has worked alongside notable professionals such as Lasse Ebdrup Pedersen and Bernhard O. Palsson. These collaborations have fostered an environment of shared knowledge and expertise, leading to groundbreaking advancements in the production of recombinant proteins and their applications in various biotechnological fields.

Conclusion

Bjørn Gunnar Voldborg's contributions to the field of biochemistry and biotechnology underscore his stature as an innovator and inventor. His patents on glycosylation methods and engineered mammalian cells highlight his role in advancing the production of recombinant proteins, making a considerable impact within research and industry. Voldborg's work is a testament to the importance of innovation in enhancing biological processes and developing efficient manufacturing techniques in biotechnology.