The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 20, 2021
Filed:
Apr. 25, 2017
Applicants:
Danmarks Tekniske Universitet, Lyngby, DK;
The Regents of the University of California, Oakland, CA (US);
Inventors:
Bjørn Gunnar Voldborg, Hillerød, DK;
Lasse Ebdrup Pedersen, Copenhagen, DK;
Bernhard Palsson, San Diego, CA (US);
Assignees:
DANMARKS TEKNISKE UNIVERSITET, Lyngby, DK;
THE REGENTS OF THE UNIVERSITY OF CALIFORNIA, Oakland, CA (US);
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 5/071 (2010.01); C12N 9/64 (2006.01); C12N 15/113 (2010.01); C12N 15/62 (2006.01); C12N 15/79 (2006.01);
U.S. Cl.
CPC ...
C12N 5/0682 (2013.01); C12N 9/6413 (2013.01); C12N 15/113 (2013.01); C12N 15/62 (2013.01); C12N 15/79 (2013.01); C12N 2510/02 (2013.01);
Abstract
The present invention relates to mammalian cells modified to provide for improved expression of a recombinant protein of interest. In particular, the invention relates to CHO cells and other host cells in which the expression of one or more endogenous secreted proteins has been disrupted, as well as to the preparation, identification and use of such cells in the production of recombinant proteins.