The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Apr. 11, 2023
Filed:
Nov. 16, 2018
Applicant:
Danmarks Tekniske Universitet, Kongens Lyngby, DK;
Inventors:
Bjørn Gunnar Voldborg, Hillerød, DK;
Stefan Kol, Copenhagen, DK;
Anders Holmgaard Hansen, Rødovre, DK;
Helene Faustrup Kildegaard, Værløse, DK;
Assignee:
DANMARKS TEKNISKE UNIVERSITET, Kongens Lyngby, DK;
Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12P 21/00 (2006.01); C07K 14/81 (2006.01); C12N 9/10 (2006.01);
U.S. Cl.
CPC ...
C12P 21/005 (2013.01); C07K 14/81 (2013.01); C12N 9/1081 (2013.01); C12Y 204/99001 (2013.01);
Abstract
The present invention relates to the finding of methods to shift the glycosylation profile of recombinant produced semm glycoproteins to the predominant bi-antennary form found in human plasma. This is accomplished by providing a mammalian cell line according to the invention with a series of gene disruptions and/or gene insertions that facilitate this shift.