Bian Wu

Title: Bian Wu: Innovator in Enzymatic Peptide Synthesis

Introduction

Bian Wu is a prominent inventor based in Groningen, Netherlands. He has made significant contributions to the field of enzymatic peptide synthesis, holding 2 patents that showcase his innovative approaches.

Latest Patents

Bian Wu's latest patents focus on methods for enzymatically synthesizing (oligo)peptides. One of his inventions involves peptide fragment condensation and cyclisation using a subtilisin variant with an improved synthesis over hydrolysis ratio. This method includes coupling an (oligo)peptide C-terminal ester or thioester with an (oligo)peptide nucleophile that has an N-terminally unprotected amine. Additionally, the invention describes an enzyme suitable for use as a catalyst in this process. Another patent also centers on similar enzymatic synthesis methods, emphasizing the use of a subtilisin BPN' variant with specific mutations to enhance the coupling process.

Career Highlights

Bian Wu is associated with Enzypep B.V., where he continues to develop innovative solutions in peptide synthesis. His work has positioned him as a key figure in the biotechnology sector, particularly in enzymatic applications.

Collaborations

Bian collaborates with notable colleagues, including Peter Jan Leonard, Mario Quaedflieg, and Timo Nuijens. These partnerships enhance the research and development efforts at Enzypep B.V.

Conclusion

Bian Wu's contributions to enzymatic peptide synthesis through his patents and collaborations highlight his role as an influential inventor in the biotechnology field. His innovative methods continue to advance the understanding and application of peptide synthesis.