Company Filing History:
4 out of 656 
2 out of 1,777 
1 out of 832,680 Years Active: 1997-2001
Title: Barbara S. Chapman: Innovator in Protein Complexes
Introduction
Barbara S. Chapman is a distinguished inventor based in Berkeley, CA, known for her significant contributions to the field of biotechnology. With a total of five patents to her name, she has made remarkable advancements in the development of recombinant protein complexes.
Latest Patents
One of her latest patents focuses on protein complexes having Factor VIII:C activity and their production. This invention involves expressing recombinant protein complexes with human Factor VIII:C activity in a eukaryotic host cell. The process includes transforming the host cell with first and second expression cassettes that encode polypeptides substantially homologous to the human Factor VIII:C A and C domains. Notably, the first polypeptide can be extended at its C-terminal with a human Factor VIII:C B domain N-terminal peptide, a polypeptide spacer of 3-40 amino acids, and a human Factor VIII:C B domain C-terminal peptide. Additionally, the expression of the second polypeptide is enhanced by utilizing an α1-antitrypsin signal sequence.
Career Highlights
Throughout her career, Barbara has worked with prominent companies in the biotechnology sector, including Chiron Corporation and Novo Nordisk A/S. Her work has significantly impacted the development of therapeutic proteins, particularly in the area of hemophilia treatment.
Collaborations
Barbara has collaborated with notable colleagues such as Rae Lyn Burke and Mirella Ezban Rasmussen, contributing to various projects that advance the field of protein engineering.
Conclusion
Barbara S. Chapman is a pioneering inventor whose work in recombinant protein complexes has the potential to transform therapeutic approaches in medicine. Her innovative spirit and dedication to research continue to inspire advancements in biotechnology.
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