Company Filing History:
Years Active: 2003-2007
Title: Barbara A. Qurollo: Innovator in Gene Expression Control
Introduction
Barbara A. Qurollo is a distinguished inventor based in Somerville, MA (US). She has made significant contributions to the field of gene expression control, holding a total of 3 patents. Her work focuses on innovative methods derived from bacterial quorum sensing systems, which have implications for eukaryotic cells and organisms.
Latest Patents
One of her latest patents involves the control of gene expression in eukaryotic cells through DNA constructs and other compositions. This invention incorporates one or more cis elements from the luxI promoter, known as the 'lux box', into a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators interacts with the lux box upon binding an acylated homoserine lactone (AHL) compound, thereby modulating the activity of the promoter. This groundbreaking approach has the potential to enhance the understanding and manipulation of gene expression in various biological contexts.
Career Highlights
Barbara A. Qurollo is currently associated with Calgene Corporation, where she continues to advance her research in gene expression. Her innovative work has positioned her as a key figure in the field, contributing to the development of new methodologies that leverage bacterial systems for eukaryotic applications.
Collaborations
Throughout her career, Barbara has collaborated with notable colleagues, including Tim N. Oulmassov and Kevin E. McBride. These partnerships have fostered a collaborative environment that enhances the research and development of her innovative ideas.
Conclusion
Barbara A. Qurollo's contributions to gene expression control exemplify the impact of innovative thinking in biotechnology. Her patents and ongoing work continue to pave the way for advancements in genetic research and applications.