Calgene Corporation

Barbara A Qurollo

Kevin E McBride

Lyle Dean Crossland

Tim N Oulmassov

Paula C Miller

John C Anderson

Victoria Gavrias

Thomas H Adams

DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter ('lux box') or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

Control of gene expression in eukaryotic cells

DNA constructs and other compositions and methods for controlling gene expression in eukaryotic cells and organisms are derived from bacterial quorum sensing systems. One or more cis elements from the luxI promoter (&ldquo;lux box&rdquo;) or a functionally similar sequence are incorporated in a eukaryotic promoter. A receptor protein from the LuxR family of transcriptional regulators, upon binding an acylated homoserine lactone (AHL) compound, interacts with the lux box, modulating the activity of the promoter.

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Somerville, MA, United States of America

Barbara A Qurollo