Barbara A Chandler

Title: Barbara A Chandler: Innovator in Cell Processing Technologies

Introduction

Barbara A Chandler is a notable inventor based in Lexington, MA (US). She has made significant contributions to the field of cell processing, holding a total of 3 patents. Her work focuses on innovative methods for enhancing the recovery and processing of biological cells.

Latest Patents

One of her latest patents is titled "Removal of agent from cell suspension." This invention relates to a method of removing an agent from a suspension of cells using a semi-permeable membrane. In one aspect of the invention, the cells are utilized to bioprocess a biological fluid after the agent's removal. Another significant patent is "High flow technique for harvesting mammalian cells." This invention is based on the observation that significant portions of porcine livers remain intact after perfusion by standard methods. It suggests that the perfusion procedures employed do not result in complete enzymatic digestion, leading to lower recovery rates of viable cells. Chandler's method combines increased perfusion flow rate, occlusion of major blood vessels, extended enzymatic digestion time, and vigorous tissue dissociation techniques to achieve a uniquely high yield of viable cells.

Career Highlights

Throughout her career, Barbara has worked with several prominent companies, including Circe Biomedical, Inc. and W.R. Grace & Co. - Conn. Her innovative approaches have significantly impacted the field of bioprocessing and cell recovery.

Collaborations

Chandler has collaborated with notable professionals in her field, including Shawn P Cain and Kermit M Borland. These collaborations have further enhanced her research and development efforts.

Conclusion

Barbara A Chandler's contributions to cell processing technologies demonstrate her innovative spirit and dedication to advancing the field. Her patents reflect her commitment to improving biological fluid processing and cell recovery methods.