Company Filing History:
2 out of 15,471 
2 out of 3,975 
Years Active: 1992-1996
Title: Babetta L Marrone: Innovator in DNA Fragment Analysis
Introduction
Babetta L Marrone is a distinguished inventor based in Los Alamos, NM (US). She has made significant contributions to the field of DNA analysis, holding a total of 4 patents. Her innovative methods have advanced the understanding and application of DNA fragment sizing and sequencing.
Latest Patents
One of her latest patents is focused on DNA fragment sizing and sorting by laser-induced fluorescence. This method utilizes high-speed detection systems, such as flow cytometry, to determine unique characteristics of DNA pieces from a sample. The process involves fragmenting the DNA at preselected sites to produce multiple DNA fragments. These fragments are treated with a dye that stains them stoichiometrically. The fluorescence emitted from the stained fragments is then analyzed to generate data related to the number of nucleotides in each fragment. The intensity of the fluorescence emissions is linearly related to the fragment length, providing a characterization of the DNA piece for forensic and research applications.
Another notable patent is the method for rapid base sequencing in DNA and RNA with two-base labeling. This technique employs fluorescent detection of single molecules at two wavelengths. Modified bases that accept fluorescent labels are used to replicate a single DNA or RNA strand for sequencing. The bases are sequentially cleaved from the replicated strand and excited with electromagnetic radiation, allowing for the detection of fluorescence from individual, tagged bases in the order of cleavage.
Career Highlights
Babetta has worked with prestigious institutions, including the University of California and the United States of America as represented by the United States. Her work has significantly impacted the field of molecular biology and genetics.
Collaborations
Throughout her career, Babetta has collaborated with notable colleagues such as Daniel J Simpson and James H Jett. These partnerships have further enhanced her research and contributions to the scientific community.
Conclusion
Babetta L Marrone's innovative work in DNA analysis has paved the way for advancements in forensic and research applications. Her patents reflect her commitment to enhancing our understanding of genetic material and its implications.