Location History:
- Fukushima, JP (2000)
- Ohwashi Tsukuba, Ibaraki JP (2011)
Company Filing History:
1 out of 314 
2 out of 832,680 Years Active: 2000-2011
Title: Ayako Saito: Innovator in Trehalose Transport and Mucosal Immunity
Introduction
Ayako Saito is a prominent inventor based in Fukushima, Japan. She has made significant contributions to the fields of cell biology and immunology, holding 2 patents that showcase her innovative research.
Latest Patents
One of her latest patents is a method of increasing cell permeability to trehalose by recombinantly producing a trehalose transporter. This invention involves the identification of a trehalose transporter gene, leading to the introduction of trehalose into cells. The gene, designated as Tret1, encodes a 504 amino acid protein with 12 trans-membrane structures. Tret1 expression is induced by desiccation stress and is predominantly found in the fat body. Functional expression of TRET1 in oocytes demonstrated that the transport activity is specific for trehalose and is independent of extracellular pH and electrochemical membrane potential. The transport direction of TRET1 is reversible, depending on the concentration gradient of trehalose, with extraordinarily high values for apparent Km and Vmax. These findings indicate that TRET1 is a facilitated, high-capacity trehalose-specific transporter, which is widespread in insects. Furthermore, TRET1 has conferred trehalose permeability upon cells, including those of vertebrates.
Another significant patent by Saito is a method for inducing mucosal immunity. This method involves injecting plasmid DNAs or oligonucleotides containing a specific DNA sequence into mammalian mucosal cells. This process induces mucosal immunity and promotes the development of CD4 positive T cells capable of producing interleukin 10 and IFN-γ.
Career Highlights
Throughout her career, Ayako Saito has worked with notable companies, including Taisho Pharmaceutical Co., Ltd. Her research has significantly impacted the understanding of trehalose transport and mucosal immunity.
Collaborations
Saito has collaborated with esteemed colleagues, including Yukio Sato and Atsushi Irisawa, contributing to her innovative research and advancements in her field.
Conclusion
Ayako Saito's work in trehalose transport and mucosal immunity exemplifies her dedication to scientific innovation. Her patents reflect her commitment to advancing knowledge in cell biology and immunology.
Inventor’s Patent Attorneys refers to legal professionals with specialized expertise in representing inventors throughout the patent process. These attorneys assist inventors in navigating the complexities of patent law, including filing patent applications, conducting patent searches, and protecting intellectual property rights. They play a crucial role in helping inventors secure patents for their innovative creations.