This inventor holds 2 USPTO granted patents. Top assignee: Other. Active years: 2010-2012.
Location History:
- Kashiwazaki-shi, Kanagawa, JP (2010)
- Kawasaki, JP (2012)
Company Filing History:
2 out of 834,453 Years Active: 2010-2012
Title: Ayako Kakegawa: Innovator in Periodontal Regeneration
Introduction
Ayako Kakegawa is a prominent inventor based in Kawasaki, Japan. She has made significant contributions to the field of periodontal regeneration, focusing on the effects of porcine sheath proteins. With a total of 2 patents, her work has garnered attention for its potential applications in dental health.
Latest Patents
Kakegawa's latest patents include a study on the effect of porcine sheath proteins on the regeneration activity of the periodontal ligament. The purpose of this research was to identify periodontal regeneration factors in enamel protein that induce cementum- and osteo-promotive activities in vivo. The study utilized experimental cavities prepared in a buccal dehiscence dog model to examine cementum regeneration (CR) activity. The results indicated that the aggregate of sheath proteins, along with a small amount of amelogenins, exhibited CR activity. The sheath proteins were purified to be homogeneous and were tested for their alkaline phosphatase (ALP) inducing activity in human periodontal ligament (HPDL) cells. Notably, the application of a 17 kDa sheath protein induced ALP activity in HPDL cells, and peptides synthesized from the sheath protein sequence also demonstrated ALP inducing activity. This 17 kDa sheath protein has shown cell differentiation activity, highlighting its potential in periodontal therapies.
Career Highlights
Throughout her career, Kakegawa has focused on innovative research that bridges the gap between basic science and clinical applications. Her work has contributed to a deeper understanding of periodontal regeneration, which is crucial for improving dental treatments and patient outcomes.
Collaborations
Kakegawa has collaborated with notable colleagues, including Kazuhiro Gomi and Makoto Fukae. These partnerships have enhanced her research efforts and expanded the impact of her findings in the field.
Conclusion
Ayako Kakegawa is a trailblazer in the field of periodontal regeneration, with her innovative research paving the way for advancements in dental health. Her contributions, particularly in the study of porcine sheath proteins, hold promise for future therapeutic applications.