The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
May. 25, 2010
Filed:
Apr. 06, 2006
Makoto Fukae, Tokyo, Tokyo, JP;
Kazuhiro Gomi, Atsugi-shi, Kanagawa, JP;
Mikimoto Kanazashi, Yokohama-shi, Kanagawa, JP;
Shinichiro Oida, Yokohama-shi, Kanagawa, JP;
Takatoshi Nagano, Tokyo, Tokyo, JP;
Takako Tanabe, Kashiwazaki, JP;
Yukiko Tanabe, Legal Representative, Kashiwazaki-shi, Niigata, JP;
Ayako Kakegawa, Kashiwazaki-shi, Kanagawa, JP;
Makoto Fukae, Tokyo, Tokyo, JP;
Kazuhiro Gomi, Atsugi-shi, Kanagawa, JP;
Mikimoto Kanazashi, Yokohama-shi, Kanagawa, JP;
Shinichiro Oida, Yokohama-shi, Kanagawa, JP;
Takatoshi Nagano, Tokyo, Tokyo, JP;
Takako Tanabe, Kashiwazaki, JP;
Yukiko Tanabe, legal representative, Kashiwazaki-shi, Niigata, JP;
Ayako Kakegawa, Kashiwazaki-shi, Kanagawa, JP;
Other;
Abstract
The purpose of this study was to identify the periodontal regeneration factors in enamel protein shown to induce cementum- and osteo-promotive activities in vivo. The cementum regeneration (CR), a part of periodontal regeneration, was examined by using experimental cavities prepared in a buccal dehiscence dog model. The CR activity was found in the aggregate consisted of sheath proteins along with a small amount of amelogenins separated from newly formed secretory enamel. The sheath proteins were purified to be homogeneous, and examined for the alkaline phosphatase (ALP) inducing activity of human periodontal ligament (HPDL) cells. Application of 17 kDa sheath protein induced ALP activity in HPDL cells. Peptides synthesized from the sheath protein sequence also showed ALP inducing activity. The 17 kDa sheath protein has cell differentiation activity.