Company Filing History:
5 out of 208 
1 out of 48 
1 out of 832,891 Years Active: 1977-1990
Title: Arpad Grein: Innovator in Antitumor Antibiotics
Introduction
Arpad Grein is a notable inventor based in Milan, Italy. He has made significant contributions to the field of pharmaceuticals, particularly in the development of antitumor antibiotics. With a total of 7 patents, Grein's work has had a profound impact on medical science.
Latest Patents
One of Grein's latest patents involves biosynthetic anthracyclines related to daunorubicin. These compounds are prepared through a biosynthetic process that incorporates the sodium salt of 1,3-N,N-dimethylbarbituric acid and 2-thiobarbituric acid during the fermentation of various microorganisms, including Streptomyces peucetius and its mutants. The resulting novel compounds exhibit strong antibacterial and antitumor activity. Additionally, he has developed anthracycline glycosides W, X, Y, and Z, which are produced by fermenting mutant F.I. 416 of Streptomyces peucetius var. caesius. These new compounds are effective against both gram-positive and gram-negative bacteria, as well as serving as antitumor agents.
Career Highlights
Throughout his career, Grein has worked with prominent companies in the pharmaceutical industry, including Farmitalia Carlo Erba S.p.a. His innovative research has led to advancements in antibiotic treatments and cancer therapies.
Collaborations
Grein has collaborated with esteemed colleagues such as Giuseppe Cassinelli and Sergio Merli. Their combined expertise has contributed to the success of various projects in the field of pharmaceuticals.
Conclusion
Arpad Grein's contributions to the development of antitumor antibiotics and his innovative research in biosynthetic processes highlight his importance in the pharmaceutical industry. His work continues to influence medical science and improve treatment options for patients.