Farmitalia Carlo Erba

Other

Societa' Farmaceutici Italia

Arpad Grein

Giuseppe Cassinelli

Giovanni Rivola

Sergio Merli

Aurelio Di Marco

Graziana Canevazzi

Marcello Gaetani

Piergiuseppe Orezzi

##STR1## are prepared by a biosynthetic process based on the addition of sodium salt of 1,3-N,N-dimethylbarbituric acid and 2-thiobarbituric acid respectively during the fermentation process of different micro-organisms such as Streptomyces peucetius and its mutants. The novel compounds are provided with good antibacterial and antitumour activity.

Biosynthetic anthracyclines related to daunorubicin

Anthracycline glycosides W, X, Y and Z which are prepared by the fermentation of mutant F.I. 416 of Streptomyces peucetius var. caesius. The new compounds are useful against both gram positive and gram negative bacteria and as antitumor agents.

Antitumor antibiotics

Anthracycline antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Micromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under number No. 31366 ATCC.

Preparation of II-deoxy anthracycline antibiotics

11-Deoxy-carminomycin compounds

Anthracycling antibiotics of the formula: ##STR1## wherein R is --CO--CH.sub.2 OH, --CHOH--CH.sub.3, --CO--CH.sub.3 or --CH.sub.2 --CH.sub.3 having antitumor and antibacterial activity are prepared by culturing a new mutant strain of microorganism designated as Macromonospora peucetica sp. nova and which has been deposited with the American Type Culture Collection under numbr No. 31366 ATCC.

Preparation of 11-deoxy anthracycline antibiotics

11-Deoxy anthracycline antibiotics, their preparation and use

1. A process for the preparation of a new antibiotic F.I. 1762, which comprises cultivating the Streptomyces 1762 under aerobic conditions in a liquid nutrient medium containing a carbon source, a nitrogen source and mineral salts, at a temperature between 25.degree. and 37.degree. C, over a period of time from 3 to 7 days, and extracting the formed antibiotic from the fermentation broth at a pH between 8 and 9 by means of a water-immiscible solvent, isolating and purifying the antibiotic F.I. 1762.

Growing community of inventors

Milan, Italy

Arpad Grein