Ariana Mostafa

Title: The Innovative Contributions of Ariana Mostafa

Introduction

Ariana Mostafa is a prominent inventor based in San Diego, California. She has made significant contributions to the field of nucleic acid detection, holding a total of 14 patents. Her work focuses on developing advanced assays that enhance the detection of target nucleic acids without the need for amplification.

Latest Patents

One of her latest patents is centered around detection assays. This invention presents a nucleic acid-guided nuclease cascade assay that can detect one or more target nucleic acids of interest without amplifying them. The assay utilizes signal amplification mechanisms that include nucleic acid-guided nucleases and guide RNAs (gRNAs) forming ribonucleoprotein complexes, along with blocked primer molecules, template molecules, polymerases, and reporter moieties. Another notable patent involves tuning cascade assay kinetics via molecular design. This disclosure relates to compositions and assay methods that allow for the control of reaction kinetics of the cascade assay by two orders of magnitude through the molecular design of one of the reaction components. This innovation enables quantification of target nucleic acids over a wide range of concentrations and can discriminate between extremely low copy numbers of target nucleic acids.

Career Highlights

Ariana has worked with several companies, including Vedabio, Inc. and Labsimply, Inc. Her experience in these organizations has contributed to her expertise in the field of molecular biology and assay development.

Collaborations

Some of her notable coworkers include Anurup Ganguli and Jacob Berger. Their collaborative efforts have further advanced the research and development of innovative detection methods.

Conclusion

Ariana Mostafa's contributions to the field of nucleic acid detection through her patents and collaborations highlight her role as a leading inventor. Her innovative approaches continue to push the boundaries of scientific research and application.