Antonio Giuseppe Gianotti

Title: Antonio Giuseppe Gianotti: Innovator in Magnetic Resonance Technology

Introduction

Antonio Giuseppe Gianotti is a prominent inventor based in Heidelberg, Germany. He has made significant contributions to the field of magnetic resonance technology, holding a total of 3 patents. His work focuses on enhancing the capabilities of magnetic resonance imaging (MRI) and related techniques.

Latest Patents

Gianotti's latest patents include an MRI compatible method and device for rapid dynamic nuclear polarization (DNP) on a solid-state hyperpolarized sample material. This innovative method involves preparing a target material containing high γ nuclei with a short T1, a polarizing agent with a broad electron paramagnetic resonance (EPR) line, and low γ nuclei with a long T1. The polarizing agent is irradiated with microwave radiation while the target material is maintained at cryogenic temperatures and exposed to a static magnetic field of at least 4.0 T. This process polarizes the high γ nuclei through DNP, allowing for the transfer of polarization to the low γ nuclei via cross polarization. The result is a dissolved sample material containing hyperpolarized low γ nuclei, which can be quickly hyperpolarized to a high polarization level.

Another notable patent is a field cycling method for magnetic resonance. This NMR experiment focuses on hyperpolarizable magnetic nuclei of substrate molecules in living human or animal bodies. It involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (NH-PHIP) into a singlet/pseudo singlet state in a low magnetic field. The substrate molecules are then injected into the living body, which is previously located inside a magnet at low magnetic field. The magnet is switched on to a high magnetic field, converting the singlet state into observable magnetization, allowing for MRI or MRS measurements with reduced losses of magnetization due to relaxation processes.

Career Highlights

Gianotti has worked with notable organizations such as Bruker Biospin GmbH and the University of York. His experience in these institutions has contributed to his expertise in magnetic resonance technologies and their applications in medical imaging.

Collaborations

Some of his notable coworkers include Simon Benedict Duckett and Joost Lohman. Their collaborative efforts have further advanced the field of magnetic resonance research.

Conclusion

Antonio Giuseppe Gianotti is a distinguished inventor whose work in magnetic resonance technology