Bruker Biospin Gmbh

University of York

Ecole Polytechnique Federale De Lausanne

Bruker Biospin Ag

Ecole Polytechnique Féderale De Lausanne (epfl)

Antonio Giuseppe Gianotti

Simon Benedict Duckett

Joost Lohman

Martin Hofmann

Geoffrey Bodenhausen

Frank Engelke

Sami Jannin

Aurélien Bornet

Gary George Green

Roberto Melzi

Gary George Reginald Green

A method for producing hyperpolarized sample material for use in magnetic resonance investigations involves preparing a target material containing high &#x3b3; nuclei with a short T, a polarizing agent with a broad EPR line, and low &#x3b3; nuclei with a long T. The polarizing agent in the target material is irradiated with microwave radiation, wherein the target material is at a cryogenic temperature and exposed to a static magnetic field B&#x2267;4.0 T, thus polarizing the high &#x3b3; nuclei by DNP, and the polarization is transferred from the high &#x3b3; nuclei to the low &#x3b3; nuclei by Cross Polarization. A dissolved sample material is prepared containing the hyperpolarized low &#x3b3; nuclei from the target material. Nuclei with a long longitudinal relaxation time Tcan thereby be quickly hyperpolarized to a high polarization level.

MRI compatible method and device for rapid DNP on a solid state hyperpolarized sample material

An NMR experiment on hyperpolarizable magnetic nuclei of substrate molecules in a living human or animal body, involves polarizing the substrate molecules by non-hydrogenating para-hydrogen induced polarization (=NH-PHIP) into a singlet/pseudo singlet state in low magnetic field and injecting the substrate molecules into the living body, the body or a part thereof being previously located inside a magnet at low magnetic field. The magnet is switched on to high magnetic field, and in at least part of the substrate molecules, the singlet state/pseudo singlet state is converted into observable magnetization. An MRI or MRS measurement is carried out with the living body or the part thereof, collecting data from the substrate molecules. The NMR experiment is well applicable on hyperpolarized nuclei within a patient, with reduced losses of magnetization due to relaxation processes.

Field cycling method for magnetic resonance

The invention relates to a device () for the preparation and measurement of a nuclear spin resonance (NMR) measurement sample (), including&#x2014;a flow-through NMR probehead (), with a first tube () and a second tube () each for the supply and removal of a liquid NMR measurement sample (),&#x2014;at least one chamber () which is connected to one of the tubes (),&#x2014;a sample inlet () for introducing the liquid measurement sample () into the device (), wherein at least one chamber () has at least one connection for increasing () and releasing () the gas pressure, and in which at least one chamber () comprises means for mixing the liquid measurement sample () contained in the chamber () with a gas With the inventive device it is possible to reduce the measurement sample consumption when doing an NMR spectroscopic measurement on liquid measurement samples to which spin order can be catalytically transferred.

NMR measurement apparatus with flow-through probehead

Growing community of inventors

Heidelberg, Germany

Antonio Giuseppe Gianotti