Company Filing History:
Years Active: 2005
Title: Antonella Marchetti: Innovator in Hepatitis C Research
Introduction
Antonella Marchetti is a prominent inventor based in Cascia, Italy. She has made significant contributions to the field of molecular biology, particularly in the development of peptide inhibitors for the hepatitis C virus. Her innovative work has the potential to impact the treatment of this viral infection.
Latest Patents
Marchetti holds a patent for "Peptide inhibitors of hepatitis C virus NS3 protease." This patent describes fluorinated oligopeptides, especially those containing 4,4-difluoro-2-amino butyric acid at the C terminus, which may serve as effective inhibitors of the hepatitis C virus NS3 protease. The invention includes examples of hexapeptides optimized for binding in the S1 specificity pocket of the enzyme, displaying inhibitory concentrations at the sub-micromolar level. Additionally, embodiments of tripeptides with a keto-acid group at the C-terminus are also noted as potent inhibitors of NS3 protease. She has 1 patent to her name.
Career Highlights
Marchetti is affiliated with the Istituto di Ricerche di Biologia Molecolare P. Angeletti Spa, where she conducts her research. Her work is characterized by a strong focus on developing therapeutic solutions for viral infections, showcasing her dedication to advancing medical science.
Collaborations
Throughout her career, Antonella has collaborated with notable colleagues, including Victor Matassa and Frank Narjes. These partnerships have contributed to her research and the successful development of her patented inventions.
Conclusion
Antonella Marchetti is a key figure in the fight against hepatitis C, with her innovative peptide inhibitors paving the way for potential new treatments. Her contributions to molecular biology highlight the importance of research in combating viral diseases.