The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Mar. 15, 2005
Filed:
Jun. 09, 1999
Victor Matassa, Vellehi, IT;
Frank Narjes, Ariccia, IT;
Konrad Forster Koehler, Huddinge, SE;
Jesus Ontoria, Barcelona, ES;
Marco Poma, Monte Argentario, IT;
Antonella Marchetti, Cascia, IT;
Victor Matassa, Vellehi, IT;
Frank Narjes, Ariccia, IT;
Konrad Forster Koehler, Huddinge, SE;
Jesus Ontoria, Barcelona, ES;
Marco Poma, Monte Argentario, IT;
Antonella Marchetti, Cascia, IT;
Abstract
Fluorinated oligopeptides, especially those having 4,4-difluoro-2-amino butyric acid at the C terminus, may be effective inhibitors of hepatitis C virus NS3 protease. Examples of hexapeptides of the invention, optimized for binding in the S1 specificity pocket of the enzyme, may display ICs at the sub-micromolar level. Embodiments of tripeptides of the invention, having a keto-acid group at the C-terminus are, likewise, potent inhibitors of NS3 protease.