Rockville, MD, United States of America

Anthony R Kalica


Average Co-Inventor Count = 7.2

ph-index = 2

Forward Citations = 34(Granted Patents)


Company Filing History:


Years Active: 1982-1986

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2 patents (USPTO):Explore Patents

Title: The Innovations of Anthony R Kalica

Introduction

Anthony R Kalica is a notable inventor based in Rockville, MD (US). He has made significant contributions to the field of vaccine development, particularly in relation to rotaviruses. With a total of 2 patents, his work has had a profound impact on public health.

Latest Patents

Kalica's latest patents include "Genetic reassortment of rotaviruses for production of vaccines" and "Cultivatable human rotavirus type 2." The first patent focuses on processes used to produce, isolate, and characterize human rotavirus/animal rotavirus reassortants. This invention aims to create live attenuated vaccines and vaccine precursors by utilizing high titer hyperimmune antisera or monoclonal antisera to select reassortants with the desired human phenotype. A key finding is that antiserum or monoclonal antisera with high titer neutralizing activity against specific glycoproteins can effectively select reassortant rotaviruses. The second patent relates to a precursor for a rotavirus vaccine designed to protect infants and young children from diarrhea caused by rotavirus. This invention involves the efficient propagation of a strain of human rotavirus type 2 through multiple passages in gnotobiotic piglets and subsequent cultivation in African green monkey kidney (AGMK) cell cultures.

Career Highlights

Throughout his career, Kalica has worked with esteemed organizations, including the United States of America as represented by the Department of Health and the United States of America as represented by the Secretary of Health. His work has been instrumental in advancing vaccine technology and improving health outcomes.

Collaborations

Kalica has collaborated with notable individuals in his field, including Harry B Greenberg and Richard G Wyatt. These collaborations have contributed to the success of his innovative projects.

Conclusion

Anthony R Kalica's contributions to vaccine development, particularly in the area of rotaviruses, highlight his importance as an inventor. His patents reflect a commitment to improving public health through innovative solutions.

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