Annie C Chang

Title: **Annie C. Chang: A Pioneer in Protein Production and Peptide Cleavage Innovations**

Introduction

Annie C. Chang, an inventive force based in Palo Alto, CA, has made significant contributions to the field of biotechnology. With three patents to her name, she has spearheaded advancements that enhance our understanding of protein production and peptide cleavage techniques. Her innovations stand as a testament to her dedication and expertise in molecular biology.

Latest Patents

One of Chang's most notable patents, titled "Protein production at synthetic start site," outlines methods and compositions for producing heterologous proteins in microbial hosts, particularly bacteria. This innovative approach allows for the insertion of heterologous genes into vectors containing endogenous genes, with the added advantage of including a ribosomal binding site. This technique has significant implications for the production of heterologous enzymes functional in bacterial hosts.

Another pivotal patent by Chang, "Site directed peptidase cleavage," details a method designed to prepare peptides devoid of unwanted amino acids or sequences. By utilizing site-specific receptors and proteases to cleave unprotected enzymatically hydrolyzable bonds, this method provides a refined mechanism to produce precise peptides for various applications.

Career Highlights

Annie C. Chang has cultivated her expertise within notable institutions, including Leland Stanford Junior University and Cetus Corporation. Her roles in these organizations have enabled her to merge academic insights with practical applications, fostering a productive environment for innovation and discovery.

Collaborations

Throughout her career, Chang has worked alongside distinguished colleagues, including Stanley N. Cohen and Hermann G. Bujard. These collaborations have not only enriched her research but also contributed to the broader scientific community’s understanding of protein chemistry.

Conclusion

Annie C. Chang is a trailblazer in her field, with a remarkable legacy characterized by her innovative patents and impactful collaborations. Her work continues to inspire researchers and professionals alike, affirming her place as a leading figure in the biotechnology arena.