Company Filing History:
Years Active: 1998-2014
Title: Andrey S Shaw: Innovator in Kinase Research
Introduction
Andrey S Shaw is a prominent inventor based in St. Louis, MO (US). He has made significant contributions to the field of kinase research, holding a total of 4 patents. His work focuses on the mechanisms of KSR kinase and its implications in signal transduction.
Latest Patents
Shaw's latest patents include innovative methods and uses of KSR kinase, as well as mutations thereof. His research discloses mutant KSR proteins that feature single amino acid substitutions, which can lead to either a loss of kinase activity or a loss of scaffolding activity. Additionally, he has developed methods for screening compounds that inhibit KSR kinase activity or KSR scaffolding activity. These screening methods often utilize protein complementation assays, where nucleic acids encoding fusion constructs are expressed in cells. Inhibitors of dimerization can be identified by a loss of enzyme activity. Another significant patent involves the inhibition of intracellular signal transduction by 14-3-3-binding peptides. This patent outlines compositions and methods that inhibit the activation of a signal transducing protein through phosphoserine-containing peptides derived from the Raf-1 protein. These peptides bind to 14-3-3 protein, preventing its association with the signal transducing peptide and effectively blocking signal transduction.
Career Highlights
Andrey S Shaw is affiliated with Washington University, where he continues to advance his research in kinase activity and signal transduction. His work has garnered attention for its potential applications in pharmacology and therapeutic interventions.
Collaborations
Shaw collaborates with notable colleagues, including Anthony J Muslin and Gabriel Waksman, contributing to a dynamic research environment that fosters innovation and discovery.
Conclusion
Andrey S Shaw's contributions to kinase research and signal transduction highlight his role as a leading inventor in the field. His patents reflect a commitment to advancing scientific knowledge and developing new therapeutic strategies.