Company Filing History:
Years Active: 2012-2016
Title: Innovations in Enzyme Design by Andrew Wollacott
Introduction
Andrew Wollacott is an accomplished inventor based in Cambridge, MA (US). He has made significant contributions to the field of enzyme design, particularly through computational methods. With a total of 2 patents, his work focuses on creating synthetic enzymes that can enhance various biochemical processes.
Latest Patents
Wollacott's latest patents revolve around synthetic enzymes derived from computational design. These patents disclose techniques for computationally designing enzymes, which can be used to create variations of naturally occurring enzymes as well as entirely new enzymes that do not exist in nature. The process begins with identifying functional reactive sites necessary for promoting desired reactions. Subsequently, hashing algorithms are employed to identify potential protein backbone structures, or scaffolds, that can support these functional sites. His techniques have successfully designed 32 different protein sequences exhibiting aldol reaction catalytic function, with 31 of these sequences detailed in the Sequence Listing. The patents also provide insights into how these synthetic aldolases can be differentiated from their naturally occurring counterparts.
Career Highlights
Wollacott is affiliated with the University of Washington, where he continues to advance research in enzyme design. His innovative approaches have garnered attention in the scientific community, contributing to the understanding of enzyme functionality and design.
Collaborations
He has collaborated with notable researchers such as David Baker and Alexandre Zanghellini, further enhancing the impact of his work in the field of synthetic biology.
Conclusion
Andrew Wollacott's contributions to enzyme design through computational methods represent a significant advancement in biotechnology. His innovative patents and collaborations highlight the potential for synthetic enzymes to revolutionize various applications in science and industry.
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