The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jan. 26, 2016
Filed:
Dec. 01, 2011
David Baker, Seattle, WA (US);
Alexandre Zanghellini, Seattle, WA (US);
Lin Jiang, Seattle, WA (US);
Andrew Wollacott, Cambridge, MA (US);
Daniela Grabs-röthlisberger, Seattle, WA (US);
Eric Althoff, Seattle, WA (US);
David Baker, Seattle, WA (US);
Alexandre Zanghellini, Seattle, WA (US);
Lin Jiang, Seattle, WA (US);
Andrew Wollacott, Cambridge, MA (US);
Daniela Grabs-Röthlisberger, Seattle, WA (US);
Eric Althoff, Seattle, WA (US);
University of Washington, Seattle, WA (US);
Abstract
Disclosed herein are techniques for computationally designing enzymes. These techniques can be used to design variations of naturally occurring enzymes, as well as new enzymes having no natural counterparts. The techniques are based on first identifying functional reactive sites required to promote the desired reaction. Then, hashing algorithms are used to identify potential protein backbone structures (i.e., scaffolds) capable of supporting the required functional sites. These techniques were used to design 32 different protein sequences that exhibited aldol reaction catalytic function, 31 of which are defined in the Sequence Listing. Details of these 31 different synthetic aldolases are provided, including descriptions of how such synthetic aldolases can be differentiated from naturally occurring aldolases.