This inventor holds 11 USPTO granted patents and 13 published patent applications. Top assignees: Harvard College, The Broad Institute, Inc.. Active years: 2022-2026.
Company Filing History:
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11 out of 482 
Years Active: 2022-2026
Title: Andrew Vito Anzalone: Innovator in Prime Editing Technologies
Introduction
Andrew Vito Anzalone is a prominent inventor based in Cambridge, MA (US). He has made significant contributions to the field of genetic engineering, particularly in the area of prime editing technologies. With a total of 11 patents to his name, Anzalone is recognized for his innovative approaches to modifying DNA and RNA sequences.
Latest Patents
Anzalone's latest patents include groundbreaking methods and compositions for prime editing nucleotide sequences. These compositions enable the incorporation of nucleotide changes and targeted mutagenesis in a target DNA molecule, such as a genome. The technology involves fusion proteins that comprise nucleic acid programmable DNA binding proteins and a polymerase, guided by a modified guide RNA known as PEgRNA. This innovative approach allows for precise editing of genetic material.
Additionally, he has developed methods and compositions for prime editing RNA. This technology facilitates the targeted modification of RNA molecules, which can be conducted both in vitro and in vivo. The compositions enable the incorporation of nucleotide changes, including single-nucleotide changes, insertions, or deletions. The RNA prime editors utilize nucleic acid programmable RNA binding proteins and RNA-dependent RNA polymerases, guided by a specific guide RNA.
Career Highlights
Anzalone has worked with esteemed institutions such as the Broad Institute and Harvard College. His work at these organizations has significantly advanced the field of genetic research and therapeutic applications.
Collaborations
Throughout his career, Anzalone has collaborated with notable scientists, including David R. Liu and James William Nelson. These collaborations have further enriched his research and contributed to the development of innovative technologies in genetic editing.
Conclusion
Andrew Vito Anzalone is a leading figure in the realm of prime editing technologies, with a strong portfolio of patents that reflect his innovative spirit. His contributions to genetic engineering continue to pave the way for advancements in therapeutic applications and scientific research.