The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Feb. 27, 2024

Filed:

Nov. 07, 2022
Applicants:

The Broad Institute, Inc., Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Inventors:

David R. Liu, Cambridge, MA (US);

Andrew Vito Anzalone, Cambridge, MA (US);

Jonathan Ma Levy, Cambridge, MA (US);

Xin Gao, Cambridge, MA (US);

Christopher J. Podracky, Cambridge, MA (US);

Assignees:

The Broad Institute, Inc., Cambridge, MA (US);

President and Fellows of Harvard College, Cambridge, MA (US);

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C12N 15/10 (2006.01); C12N 9/12 (2006.01); C12N 9/22 (2006.01); C12N 15/11 (2006.01);
U.S. Cl.
CPC ...
C12N 15/102 (2013.01); C12N 9/1276 (2013.01); C12N 9/22 (2013.01); C12N 15/111 (2013.01);
Abstract

The present disclosure provides systems, compositions, and methods for simultaneously editing both strands of a double-stranded DNA sequence at a target site to be edited. Further provided herein are pharmaceutical compositions, polynucleotides, vectors, cells, and kits for simultaneously editing both strands of a double-stranded DNA sequence.


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