Location History:
- Beckenham, Kent, GB (1995)
- Beckenham, GB (1995 - 1996)
Company Filing History:
2 out of 6 
1 out of 832,761 Years Active: 1995-1996
Title: **Celebrating the Innovations of Andrew J Makoff**
Introduction
Andrew J Makoff, an esteemed inventor based in Beckenham, GB, has made significant strides in the field of biotechnology. With two patents to his name, his work primarily focuses on the expression of tetanus toxin fragment C in yeast, showcasing his contributions to medical and genetic research.
Latest Patents
Andrew's latest patents revolve around the innovative expression of the tetanus toxin fragment C, achieved through a meticulously designed DNA coding sequence. This sequence notably features an increased (G+C)-content from nucleotide 410 to the 3' end as compared to the wild-type DNA sequence. This intricate design enables the production of complete mRNA transcripts, a critical aspect for further research and applications. The specific regions where the (G+C)-content is enhanced include nucleotides 510-710, 650-850, 800-1100, 900-1200, and 1100 to the 3' end of the coding sequence, which cover important terminator sequences in the wild-type DNA. Additionally, the (G+C)-content may also be elevated in the segment of nucleotides 410-610, further enriching the expression process.
Career Highlights
Andrew J Makoff’s relationship with Evans Medical Limited has been pivotal in his career. His innovative approaches and research focus have contributed to the company's advancements in biotechnology. With his strong background in science, Andrew continues to push the boundaries of what is possible in medical research.
Collaborations
Throughout his career, Andrew has worked closely with notable colleagues such as Michael A Romanos and Jeffrey J Clare. These collaborations have further fostered a rich environment for innovation and exploration in their respective fields of expertise.
Conclusion
Andrew J Makoff stands out as a prominent inventor in the biotechnology landscape. Through his innovative patents and collaborative efforts with his peers, he continues to make impactful contributions that may enhance medical breakthroughs in the future. His work not only demonstrates his ingenuity but also the potential for future advancements in genetic research.