Company Filing History:
3 out of 17 
3 out of 51 
1 out of 1 Years Active: 1996-2003
Title: The Innovative Contributions of Andrew A Pakula in Nucleic Acid Research
Introduction
Andrew A Pakula, an accomplished inventor based in Lexington, MA, has made significant contributions to the field of molecular biology through his innovative inventions. With a commendable portfolio of seven patents, Pakula has focused primarily on methods for screening bioactive compounds that interact with nucleic acids, particularly RNA.
Latest Patents
Pakula's latest patents underscore his dedication to advancing scientific research and medical applications. One of his notable inventions is the "Screen employing fluorescence anisotropy to identify compounds with affinity for nucleic acids." This invention provides methods for screening bioactive compounds that bind to RNA sequences associated with disease pathogenesis or physiological regulation. The methodology involves evaluating the stability and conformation of an RNA target in the presence of test ligands. By measuring changes in RNA stability and conformation, researchers can identify potential ligands using fluorescence polarization of a fluorescently labeled probe.
Another significant patent is the "Screen for compounds with affinity for nucleic acids," which offers high-throughput screening methods for identifying bioactive compounds. This invention similarly focuses on the interaction of test ligands with RNA sequences, assessing conformational changes in RNA targets to determine ligand efficacy.
Career Highlights
Throughout his career, Andrew Pakula has collaborated with several prominent organizations, including Scriptgen Pharmaceuticals, Inc. and Anadys Pharmaceuticals, Inc. His diverse experiences within these companies have undoubtedly enriched his innovative approaches to nucleic acid research.
Collaborations
Collaboration has been a key aspect of Pakula's work. He has partnered with notable coworkers such as Jaime E Arenas and James W Lillie, contributing to a vibrant exchange of ideas and expertise in their respective fields. These collaborations further enhance the impact of his inventions and expand the possibilities for future research.
Conclusion
In summary, Andrew A Pakula stands out as an inventive force in the realm of nucleic acid research. His seven patents, particularly those focused on high-throughput screening methods for bioactive compounds, reflect his commitment to addressing significant scientific and medical challenges. As he continues to develop innovative solutions, Pakula's contributions are poised to make lasting impacts in the field.