Andrej Premrl

Title: The Innovative Contributions of Andrej Premrl

Introduction

Andrej Premrl is a notable inventor based in Ljubljana, Slovenia. He has made significant contributions to the field of pharmaceuticals, particularly in the synthesis of angiotensin II antagonists. With a total of 3 patents to his name, his work showcases a blend of creativity and scientific rigor.

Latest Patents

Premrl's latest patents include innovative methods for synthesizing key pharmaceutical compounds. One of his notable inventions is the "Catalyzed carbonylation in the synthesis of angiotensin II antagonists." This invention details an efficient synthesis of halogenated biaryl starting materials via Grignard chemistry. It also describes the reaction of catalyzed carbonylation of specific compounds using gaseous carbon monoxide in a solvent mixture containing water or formic acid salts.

Another significant patent is focused on "2'-halobiphenyl-4-yl intermediates in the synthesis of angiotensin II antagonists." This process involves reacting halotoluene with 1,2-dihalobenzene in the presence of elemental metals. The resulting organometal intermediates are then quenched by elemental metal halogen. This patent further describes the coupling of these intermediates to produce complex pharmaceutical compounds, which can be converted into medicaments.

Career Highlights

Andrej Premrl is currently associated with Lek Pharmaceuticals D.d., a leading pharmaceutical company in Slovenia. His work at Lek Pharmaceuticals has allowed him to focus on innovative drug development, contributing to advancements in medical science.

Collaborations

Throughout his career, Premrl has collaborated with esteemed colleagues such as Zdenko Casar and Anton Copar. These collaborations have fostered a productive environment for innovation and research in the pharmaceutical sector.

Conclusion

Andrej Premrl's contributions to the field of pharmaceuticals through his patents and collaborative efforts highlight his role as a significant inventor. His work continues to influence the development of important medical treatments.