The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Patent No.:

US 8445693 B1

PDF
Full Text
Expired
Date of Patent:
May. 21, 2013

Filed:

Mar. 19, 2009
Applicants:

Zdenko Casar, Ljubljana, SI;

Anton Copar, Ljubljana, SI;

Jerome Cluzeau, Ljubljana, SI;

Andrej Premrl, Ljubljana, SI;

Inventors:

Zdenko Casar, Ljubljana, SI;

Anton Copar, Ljubljana, SI;

Jerome Cluzeau, Ljubljana, SI;

Andrej Premrl, Ljubljana, SI;

Assignee:

Lek Pharmaceuticals D.D., Ljubljana, SI;

Attorney:
Primary Examiner:
Int. Cl.
CPC ...
C07D 235/08 (2006.01);
U.S. Cl.
CPC ...
Abstract

One embodiment disclosed in the invention is the efficient synthesis of halogenated biaryl starting material via Grignard chemistry and the use thereof. Another embodiment of the invention is the reaction of catalyzed carbonylation of the 3'-(2′-halo-biphenyl-4-ylmethyl)-1,7′-dimethyl-2′-propyl-1H,3′H-[2,5′]bibenzoimidazolyl (TLMH) using either gaseous carbon monoxide in a solvent mixture containing water; or formic acid salts optionally together with acetic acid in anhydrous solvent.


Find Patent Forward Citations

Casar, Zdenko. (2013). Catalyzed carbonylation in the synthesis of angiotensin ii antagonists (U.S. Patent No. 8445693). U.S. Patent and Trademark Office. https://idiyas.com/patent/badge/8445693

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