This inventor holds 5 USPTO granted patents. Top assignees: Institut Pasteur, Centre National De La Recherche Scientifique. Active years: 1993-2000.
Location History:
- Neuilly-sur-Marne, FR (1993)
- Neuilly/Marne, FR (1999)
- Neuilly S/Marne, FR (1994 - 2000)
Company Filing History:
5 out of 897 
1 out of 5,383 
Years Active: 1993-2000
Title: The Innovative Contributions of Andre Klier
Introduction
Andre Klier is a notable inventor based in Neuilly-sur-Marne, France. He has made significant contributions to the field of biotechnology, particularly in the development of mosquitocidal microorganisms. With a total of 5 patents to his name, Klier's work has had a substantial impact on pest control methods.
Latest Patents
One of Klier's latest patents involves the creation of non-hemolytic mosquitocidal microorganisms. This invention focuses on the cytA gene, which encodes a 28 kDa polypeptide of Bacillus thuringiensis israelensis crystals. The disruption of this gene in the 72 MDa resident plasmid through in vivo recombination resulted in the absence of the 28 kDa protein. Remarkably, this absence did not affect the crystallization of other toxic components in the parasporal body. Furthermore, the mosquitocidal activity of the modified crystals remained comparable to that of the wild-type crystals. Another significant patent relates to a vector designed for transforming microorganisms capable of sporulation. This vector contains a heterologous insert that includes a DNA sequence coding for insecticidal crystal proteins, particularly from Bacillus thuringiensis. The invention also encompasses the polypeptides expressed by these microorganisms, which exhibit insecticidal properties similar to those of the crystal protein.
Career Highlights
Throughout his career, Andre Klier has worked with prestigious organizations such as Institut Pasteur and the Centre National de la Recherche Scientifique. His work in these institutions has allowed him to advance his research and contribute to significant scientific discoveries.
Collaborations
Klier has collaborated with esteemed colleagues, including Georges Rapoport and Armelle Delecluse. Their combined expertise has further enriched the research and innovations in the field of biotechnology.
Conclusion
Andre Klier's innovative work in the development of mosquitocidal microorganisms and his collaborations with leading scientists highlight his significant contributions to biotechnology. His patents reflect a commitment to advancing pest control methods and improving environmental safety.