Amy S Lee

Title: Amy S Lee: Innovator in Cancer Detection

Introduction

Amy S Lee is a prominent inventor based in San Marino, CA (US). She has made significant contributions to the field of cancer detection through her innovative research and development of antibodies targeting specific proteins on tumor cells. With a total of 6 patents, her work is paving the way for advancements in cancer therapeutics.

Latest Patents

One of her latest patents focuses on "Epitope specific antibodies that bind cell surface GRP78 and their use for cancer detection." This application provides antibodies or antigen-binding fragments that target cell surface GRP78 expressed on tumor cells, tumor endothelial cells, and tumor-initiating cancer cells. These anti-GRP78 antibodies exhibit a high affinity for GRP78 and are less immunogenic compared to their unmodified parent antibodies in humans. They function to inhibit GRP78, which is crucial for cancer cell survival. Importantly, these isolated novel antibodies and antigen-binding fragments attenuate PI3K signaling and promote apoptosis in tumor cells while leaving normal cells unaffected. This innovation is particularly useful for UPR-targeted cancer therapeutic treatments.

Another significant patent by Amy S Lee also involves "Antibodies that bind cell surface GRP78." Similar to her previous work, this application provides antibodies or antigen-binding fragments that target cell surface GRP78 on tumor cells. The high affinity and reduced immunogenicity of these antibodies make them a promising tool in cancer detection and treatment.

Career Highlights

Amy S Lee is affiliated with the University of Southern California, where she continues her research and development in the field of cancer therapeutics. Her work has garnered attention for its potential impact on cancer treatment and detection.

Collaborations

Some of her notable coworkers include Ren Liu and Parkash S Gill, who contribute to her research efforts and innovations in the field.

Conclusion

Amy S Lee is a trailblazer in the development of innovative cancer detection methods through her patented antibodies. Her contributions are vital in the ongoing fight against cancer, showcasing the importance of research and innovation in medical science.