Alvin H Schmaier

Title: The Innovations of Alvin H Schmaier

Introduction

Alvin H Schmaier is a notable inventor based in Ann Arbor, MI, with a significant contribution to the field of synthetic peptides. He holds a total of 8 patents, showcasing his expertise and innovative spirit in medical research and applications.

Latest Patents

Among his latest patents are two significant inventions related to thrombin and its activation of protease-activated receptors. The first patent focuses on synthetic peptide inhibitors of thrombin and thrombin activation of protease-activated receptors 1 and 4. This invention involves synthetic peptide analogs of D-Arg-Oic-Pro-Gly-Phe and outlines methods for their use to inhibit human platelet aggregation, thrombosis, and cell activation mediated by PAR1 and PAR4. The second patent presents synthetic peptide analogs of Arg-Pro-Pro-Gly-Phe as selective inhibitors of thrombin and thrombin activation of protease-activated receptors 1 and 4. This invention includes compounds and methods for inhibiting human platelet aggregation and thrombosis, as well as screening methods for identifying compounds that inhibit thrombin-mediated activities.

Career Highlights

Alvin H Schmaier has had a distinguished career, working at prestigious institutions such as the University of Michigan and Temple University. His work has significantly advanced the understanding of thrombin's role in platelet aggregation and thrombosis, contributing to potential therapeutic applications.

Collaborations

Throughout his career, Schmaier has collaborated with esteemed colleagues, including Ahmed A K Hasan and Robert W Colman. These collaborations have further enriched his research and innovations in the field.

Conclusion

Alvin H Schmaier's contributions to synthetic peptide research and his numerous patents highlight his role as a leading inventor in the medical field. His work continues to influence advancements in therapies for thrombin-related conditions.