The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Jul. 11, 2006
Filed:
May. 01, 2003
Applicants:
Alvin H. Schmaier, Ann Arbor, MI (US);
Ahmed A. K. Hasan, Ann Arbor, MI (US);
Inventors:
Alvin H. Schmaier, Ann Arbor, MI (US);
Ahmed A. K. Hasan, Ann Arbor, MI (US);
Assignees:
The Regents of the University of Michigan, East Lansing, MI (US);
Thromgen, Inc., Ann Arbor, MI (US);
Attorneys:
Primary Examiner:
Int. Cl.
CPC ...
A61K 38/08 (2006.01); A61K 39/16 (2006.01); C07K 7/18 (2006.01); C07K 14/00 (2006.01);
U.S. Cl.
CPC ...
Abstract
The invention relates to compounds and methods for inhibiting human platelet aggregation, thrombosis and cell activation mediated by PAR1 and PAR4 using peptide analogs of Arg-Pro-Pro-Gly-Phe that contain one or more amino acid substitutions. The invention also includes screening methods for identifying compounds that inhibit thrombin mediated activities.