Alfred L Williams

Title: Alfred L. Williams: Innovator in Glucuronidase Inhibitors

Introduction

Alfred L. Williams is a notable inventor based in Durham, North Carolina. He has made significant contributions to the field of pharmacology, particularly with his innovative work on glucuronidase inhibitors. With two patents to his name, Williams has focused his research on compounds that aim to improve the efficacy of cancer treatments.

Latest Patents

Williams holds two important patents that delve into the realm of glucuronidase inhibition. His first patent, titled "Phenoxy thiophene sulfonamides and their use as inhibitors of glucuronidase," outlines compounds that serve as glucuronidase inhibitors, including phenoxy thiophene sulfonamides. This invention also considers other related compounds such as pyridine sulfonyls and thiophene carbonyls. The patent further discusses compositions that utilize these compounds to inhibit glucuronidase and their potential role as co-drugs in combination with the anticancer drug CPT-11.

The second patent, "Selective beta-glucuronidase inhibitors as a treatment for side effects of camptothecin antineoplastic agents," offers methods and compounds for inhibiting bacterial β-glucuronidases. This invention is particularly beneficial in mitigating the side effects of camptothecin-derived antineoplastic agents by addressing the reactivation of glucuronidated metabolites, thus enhancing treatment efficacy.

Career Highlights

Alfred L. Williams has had a fruitful career, engaging in meaningful research at respected institutions. He has worked at North Carolina Central University and the University of North Carolina at Chapel Hill. His research has significantly contributed to the understanding and development of glucuronidase inhibitors.

Collaborations

Throughout his career, Williams has collaborated with distinguished colleagues such as Matthew Robert Redinbo and John Scott. These partnerships have played a pivotal role in advancing his research and expanding the impact of his inventions in the scientific community.

Conclusion

Alfred L. Williams stands out as an influential inventor whose work in glucuronidase inhibitors has the potential to significantly impact cancer treatment. With his innovative patents and dedicated research career, he continues to contribute valuable insights to pharmacology and therapeutic science.