The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.

The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.

Date of Patent:
Apr. 11, 2017

Filed:

Mar. 10, 2011
Applicants:

Alfred L. Williams, Durham, NC (US);

John Scott, Durham, NC (US);

Li-an Yeh, Cary, NC (US);

Matthew Robert Redinbo, Chapel Hill, NC (US);

Inventors:

Alfred L. Williams, Durham, NC (US);

John Scott, Durham, NC (US);

Li-An Yeh, Cary, NC (US);

Matthew Robert Redinbo, Chapel Hill, NC (US);

Attorney:
Primary Examiner:
Assistant Examiner:
Int. Cl.
CPC ...
A61K 31/38 (2006.01); C07D 333/34 (2006.01); C07D 409/12 (2006.01); C07D 413/12 (2006.01); C07D 417/12 (2006.01); A61K 31/137 (2006.01); A61K 31/42 (2006.01); A61K 31/4409 (2006.01); A61K 31/4709 (2006.01); A61K 31/553 (2006.01); C07D 295/135 (2006.01); C07D 409/06 (2006.01); C12Q 1/34 (2006.01);
U.S. Cl.
CPC ...
C07D 333/34 (2013.01); A61K 31/137 (2013.01); A61K 31/42 (2013.01); A61K 31/4409 (2013.01); A61K 31/4709 (2013.01); A61K 31/553 (2013.01); C07D 295/135 (2013.01); C07D 409/06 (2013.01); C07D 409/12 (2013.01); C07D 413/12 (2013.01); C07D 417/12 (2013.01); C12Q 1/34 (2013.01); G01N 2333/924 (2013.01); G01N 2500/02 (2013.01);
Abstract

This invention relates generally to compounds that are glucuronidase inhibitors. Glucuronidase inhibitors described include phenoxy thiophene sulfonamides. Other compounds, for instance pyridine sulfonyls, benzene sulfonyls, thiophene sulfonyls, thiazole sulfonyls, thiophene carbonyls, and thiazole carbonyls, are also contemplated. Also contemplated are compositions including one or more of such compounds for use inhibiting glucuronidase and methods of using one or more of such compounds as a co-drug to be used in combination with the anticancer drug CPT-11.


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