Company Filing History:
Years Active: 2006-2008
Title: Alfio Fichera: Innovator in Fluorinated Peptides
Introduction
Alfio Fichera is a notable inventor based in Malden, MA (US). He has made significant contributions to the field of biochemistry, particularly in the development of fluorinated peptides. With a total of 2 patents, his work has implications for protein stability and design.
Latest Patents
Fichera's latest patents include "Non-racemic trifluoroleucine, and methods of making and using" and "Non-racemic hexafluoroleucine, and methods of making and using." One aspect of the first invention relates to hexafluoroleucine and its congeners, along with methods for synthesizing these compounds. Another aspect focuses on the synthesis of protein cores that incorporate hexafluoroleucine. Comparative biophysical studies have characterized certain peptides containing hexafluoroleucine, revealing that these fluorinated peptides exhibit higher thermal stability and enhanced resistance to chemical denaturation. Additionally, mixed hydrocarbon-fluorocarbon cores have been shown to self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.
Career Highlights
Fichera is affiliated with Tufts College, where he continues to advance his research in the field. His innovative work has garnered attention for its potential applications in biochemistry and molecular biology.
Collaborations
Some of his notable coworkers include Zihni Bilgicer and Krishna Kumar, who contribute to the collaborative research environment at Tufts College.
Conclusion
Alfio Fichera's contributions to the field of fluorinated peptides and protein design highlight his role as an influential inventor. His patents pave the way for advancements in biochemistry and protein engineering.