The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Nov. 07, 2006
Filed:
Feb. 25, 2002
Alfio Fichera, Malden, MA (US);
Zihni Bilgicer, Somerville, MA (US);
Krishna Kumar, Cambridge, MA (US);
Xuechao Xing, Wilmington, MA (US);
Alfio Fichera, Malden, MA (US);
Zihni Bilgicer, Somerville, MA (US);
Krishna Kumar, Cambridge, MA (US);
Xuechao Xing, Wilmington, MA (US);
Trustees of Tufts College, Medford, MA (US);
Abstract
One aspect of the invention relates to hexafluoroleucine and congeners thereof, and methods of making the compounds. Another aspect of the nvention relates to the synthesis of protein cores comprising hexafluoroleucine and congeners thereof. Certain peptides comprising hexafluorleucine and congeners thereof have been characterized using comparative biophysical studies. In general, the fluorinated peptides show higher thermal stability and enhanced resistance to chemical denaturation. Further, mixed hydrocarbonfluorocarbon cores self-sort into homogeneous bundles, suggesting new avenues for the design and manipulation of protein-protein interfaces.