Alexandra Loew-Baselli

Title: Innovations by Alexandra Loew-Baselli

Introduction

Alexandra Loew-Baselli is a prominent inventor based in Vienna, Austria. She has made significant contributions to the field of pharmacokinetics, particularly in drug dosing regimens. With a total of 3 patents to her name, her work has the potential to greatly impact patient care and treatment outcomes.

Latest Patents

Her latest patents include a method and apparatus for providing a pharmacokinetic drug dosing regimen. This innovation involves systems and methods that provide a clotting factor VIII dosing regimen. The systems determine an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients. This allows for the determination of a first dosing regimen that includes a first dosage and a first therapeutic plasma protein level, which varies over time based on the estimated pharmacokinetic profile. Additionally, the systems can adjust the estimated pharmacokinetic profile based on previous patient treatments, ensuring that the protein level does not fall below a target trough.

Another notable patent focuses on systems and methods for providing a clotting factor VIII dosing regimen. This involves collecting two blood samples from a patient after an infusion of clotting factor VIII and determining the clearance based on these samples. The pharmacokinetic profile is then established using a Bayesian model, which takes into account the patient's half-life in relation to a predetermined threshold. This innovative approach allows for a tailored dosing regimen based on the individual patient's needs.

Career Highlights

Throughout her career, Alexandra has worked with notable companies such as Baxalta GmbH and Takeda Pharmaceutical Company Limited. Her experience in these organizations has contributed to her expertise in pharmacokinetics and drug dosing.

Collaborations

Alexandra has collaborated with esteemed colleagues, including Kameswara Rao Kuchimanchi and Gerald Spotts. These partnerships have further enhanced her research and development efforts in the field.

Conclusion

Alexandra Loew-Baselli's contributions to pharmacokinetics and drug dosing regimens exemplify her innovative spirit and dedication to improving patient care. Her work continues to pave the way for advancements in medical treatments and patient outcomes.