The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Aug. 03, 2021
Filed:
Oct. 14, 2020
Baxalta Incorporated, Bannockburn, IL (US);
Baxalta Gmbh, Glattpark, CH;
Kameswara Rao Kuchimanchi, Lexington, MA (US);
Alexandra Loew-Baselli, Vienna, AT;
Gerald Spotts, Encine, CA (US);
Myungshin Oh, Los Angeles, CA (US);
Michael Don Hale, Winchester, MA (US);
Martin Wolfsegger, Vienna, AT;
BAXALTA INCORPORATED, Bannockburn, IL (US);
BAXALTA GMBH, Glattpark, CH;
Abstract
Systems and methods providing a clotting factor VIII dosing regimen are disclosed. The systems and methods include determining an estimated pharmacokinetic profile of a patient using a Bayesian model of pharmacokinetic profiles of sampled patients. The systems and methods can determine a first dosing regimen for a first dosing interval including (i) a first dosage and (ii) a first therapeutic plasma protein level in the patient varying over time based at least upon the estimated pharmacokinetic profile. The systems and methods can determine a second dosing regimen for a second dosing interval including (i) a second dosage and (ii) a second therapeutic plasma protein level in the patient varying over time. The estimated pharmacokinetic profile can be adjusted based on previous patient treatments. Further, a user can select which days a dosage is to be applied such that the protein level does not fall below a target trough.