Location History:
- Boston, MA (US) (2003 - 2006)
- Sommerville, MA (US) (2012)
- Cambridge, MA (US) (2012)
- Reading, MA (US) (2014)
Company Filing History:
5 out of 8 
1 out of 168 
Years Active: 2003-2014
Title: Innovations by Inventor Alex Avdeef
Introduction
Alex Avdeef is a notable inventor based in Reading, MA (US), recognized for his contributions to the field of permeability assays and drug absorption. He holds a total of 5 patents, showcasing his innovative approach to solving complex problems in pharmaceutical science.
Latest Patents
Among his latest patents, Avdeef has developed a permeation device and method for reducing aqueous boundary layer thicknesses. This invention provides a permeation device comprising a receiving vessel with an aperture adapted for receiving an insert well. Both the vessel and well can serve as donor or acceptor compartments for permeability assays. The device includes a porous support, which may consist of biological or biomimetic materials, allowing a molecular entity to permeate through it. In one embodiment, a stirring member within the vessel can agitate the solution to reduce aqueous boundary layer thickness adjacent to the support. This innovation aims to reduce boundary layer thicknesses to less than about 15 micrometers, closely approximating in vivo absorption and transport conditions.
Another significant patent by Avdeef is a method for assessing the absorption properties of low solubility compounds. This method evaluates the effect of excipients, pH, and their combinations on the predicted absorption properties of low solubility compounds. It involves assessing changes in a flux function for a combination of a low solubility compound and an excipient at predefined pH values. This method allows for a fast, accurate, and economical evaluation of excipients capable of optimizing drug molecule absorption, thereby reducing the need for animal experiments.
Career Highlights
Throughout his career, Alex Avdeef has worked with prominent companies such as Pion Inc. and F. Hoffmann-La Roche AG. His experience in these organizations has contributed significantly to his expertise in drug formulation and permeability testing.
Collaborations
Avdeef has collaborated with notable professionals in his field, including Per E. Nielsen and Chau M. Du. These collaborations have further enhanced his research and development efforts in the pharmaceutical industry.
Conclusion
Alex Avdeef's innovative patents and contributions to drug absorption and permeability assays highlight his significant impact on pharmaceutical science. His work continues to pave the way for advancements in drug formulation and evaluation.