The patent badge is an abbreviated version of the USPTO patent document. The patent badge does contain a link to the full patent document.
The patent badge is an abbreviated version of the USPTO patent document. The patent badge covers the following: Patent number, Date patent was issued, Date patent was filed, Title of the patent, Applicant, Inventor, Assignee, Attorney firm, Primary examiner, Assistant examiner, CPCs, and Abstract. The patent badge does contain a link to the full patent document (in Adobe Acrobat format, aka pdf). To download or print any patent click here.
Patent No.:
Date of Patent:
Sep. 23, 2014
Filed:
Jun. 01, 2005
Alex Avdeef, Reading, MA (US);
Per E. Nielsen, Westlake, OH (US);
Alex Avdeef, Reading, MA (US);
Per E. Nielsen, Westlake, OH (US);
Pion, Inc., Billerica, MA (US);
Abstract
The invention provides a permeation device () comprising a receiving vessel () having an aperture adapted for receiving an insert well (). Both the vessel () and well () are used as either donor or acceptor compartments for permeability assays. The vessel () or well () comprises a porous suppor ()t, which may comprise biological or biomimetic materials, adapted for a molecular entity to permeate therethrough. In one embodiment, a stirring member () disposed in the vessel () can provide solution agitation to reduce aqueous boundary layer thickness adjacent to the support (). Boundary layer thicknesses can be reduced by a device () of the invention to less than about 15 um such that a molecular entity permeating the support closely approximates in vivo absorption and transport conditions.