Alessandro Barozza

Title: Innovations by Alessandro Barozza

Introduction

Alessandro Barozza is a notable inventor based in Nosate, Italy. He has made significant contributions to the field of chemical synthesis, holding a total of 4 patents. His work focuses on developing cost-effective and scalable processes for synthesizing important pharmaceutical compounds.

Latest Patents

One of Barozza's latest patents is a process for the synthesis of lofexidine. This process involves the use of ethyl 2-(2,6-dichlorophenoxy)propionate and ethylenediamine in the presence of tetravalent titanium alkoxides, specifically titanium isopropoxide, in an apolar solvent like toluene. The invention also includes a method for preparing the intermediate compound from 2,6-dichlorophenol and ethyl 2-chloropropionate, utilizing a polar aprotic solvent and an alkali or alkaline earth carbonate salt, such as potassium carbonate. Both processes are designed to be more cost-effective and easily scalable for industrial applications.

Another significant patent by Barozza is for the synthesis of pirfenidone. This process utilizes 5-methyl-2(1H)-pyridinone and chlorobenzene, employing a catalytic system that includes a copper salt and an organic ligand, along with a base. The method takes advantage of the efficiency of the copper(I) salt and organic ligand in the N-amidation reaction, allowing for high yields under high-temperature conditions.

Career Highlights

Alessandro Barozza is associated with Procos S.p.a., where he continues to innovate in the field of chemical synthesis. His work has contributed to advancements in pharmaceutical manufacturing, making processes more efficient and cost-effective.

Collaborations

Barozza collaborates with notable colleagues such as Jacopo Roletto and Paolo Paissoni, enhancing the innovative capacity of his team.

Conclusion

Alessandro Barozza's contributions to chemical synthesis through his patents demonstrate his commitment to innovation in the pharmaceutical industry. His work not only improves the efficiency of drug production but also highlights the importance of collaboration in advancing scientific research.